{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/83551"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/83551","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes","abstract":"The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.","abstract_html":"The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.","abstract_has_math":false,"creators":["Deszo, Eric Louis"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Freund, Gregory G."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T21:08:07Z","date_published":"2015-09-25T21:08:07Z","updated_at":"2026-07-22T22:26:21Z","subjects":["Health Sciences, Pathology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3086046"],"render_values":[{"text":"(MiAaPQ)AAI3086046","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/83551","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Freund, Gregory G."]},{"key":"dc:creator","label":"Author","values":["Deszo, Eric Louis"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T21:08:07Z","10000-01-01","2003"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pathology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/83551","(MiAaPQ)AAI3086046"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase kinase alpha. These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.","Made available in DSpace on 2015-09-25T21:08:07Z (GMT). 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These data together indicate that promyelocyte differentiation is a process that is dependent on the activity of PKCdelta. Furthermore, this process is subject to regulation by interlukin-4 induced STAT6 activation and CaMKKalpha. In conclusion we have identified possible targets for future therapies in the treatment of diabetes induced altered immunity.","Made available in DSpace on 2015-09-25T21:08:07Z (GMT). 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