Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex

The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal and nonpyramidal neurons. Given the potentially important role of corticothalamic innervation, the long-lasting excitation of deep neocortical neurons by CCK could modulate their output and ultimately have an important influence on information transfer through the thalamocortical circuit.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Neuroscience

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Chung, Leeyup

Contributors dc:contributor

• Cox, Charles L.

• Health Sciences, Pharmacology

Language dc:language

eng

Identifier

(MiAaPQ)AAI3202078

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82505