{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/82505"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/82505","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex","abstract":"The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal and nonpyramidal neurons. Given the potentially important role of corticothalamic innervation, the long-lasting excitation of deep neocortical neurons by CCK could modulate their output and ultimately have an important influence on information transfer through the thalamocortical circuit.","abstract_html":"The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal and nonpyramidal neurons. Given the potentially important role of corticothalamic innervation, the long-lasting excitation of deep neocortical neurons by CCK could modulate their output and ultimately have an important influence on information transfer through the thalamocortical circuit.","abstract_has_math":false,"creators":["Chung, Leeyup"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Cox, Charles L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T20:45:35Z","date_published":"2015-09-25T20:45:35Z","updated_at":"2026-07-22T22:26:18Z","subjects":["Health Sciences, Pharmacology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3202078"],"render_values":[{"text":"(MiAaPQ)AAI3202078","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/82505","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cox, Charles L."]},{"key":"dc:creator","label":"Author","values":["Chung, Leeyup"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T20:45:35Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pharmacology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/82505","(MiAaPQ)AAI3202078"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal and nonpyramidal neurons. Given the potentially important role of corticothalamic innervation, the long-lasting excitation of deep neocortical neurons by CCK could modulate their output and ultimately have an important influence on information transfer through the thalamocortical circuit.","Made available in DSpace on 2015-09-25T20:45:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3202078.pdf: 4247577 bytes, checksum: 3fc0e4054161bc651b2bca0bb4c949bd (MD5) Previous issue date: 2005","Embargo set by: Seth Robbins for item 83786 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","174 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005."]},{"key":"dc:title","label":"Title","values":["Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex"]}]}],"canonical_facts":{"dc:contributor":["Cox, Charles L."],"dc:creator":["Chung, Leeyup"],"dc:date":["2015-09-25T20:45:35Z","10000-01-01","2005"],"dc:description":["The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing within various thalamic nuclei. Due to the presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted in tetrodotoxin. This depolarization was mediated by CCKB subtype receptors, and resulted from a reduced linear K+ current as well as an increase in a nonselective cation current. I also found that CCK produces excitatory responses in layer V pyramidal and nonpyramidal neurons. Given the potentially important role of corticothalamic innervation, the long-lasting excitation of deep neocortical neurons by CCK could modulate their output and ultimately have an important influence on information transfer through the thalamocortical circuit.","Made available in DSpace on 2015-09-25T20:45:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3202078.pdf: 4247577 bytes, checksum: 3fc0e4054161bc651b2bca0bb4c949bd (MD5) Previous issue date: 2005","Embargo set by: Seth Robbins for item 83786 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","174 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005."],"dc:identifier":["http://hdl.handle.net/2142/82505","(MiAaPQ)AAI3202078"],"dc:language":["eng"],"dc:subject":["Health Sciences, Pharmacology"],"dc:title":["Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex"],"dc:type":["text"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:18Z"}