Interactions Between Polyethylene Glycol Chains and Proteins and Chemically Selective Surfaces

The results presented in this work directly demonstrate that far from presenting an inert and repulsive steric barrier, PEG brushes can interact differently with different chemically selective surfaces. Clearly, PEG is not an inert, simple polymer whose biological activity, especially, vis-a-vis proteins, can be solely described via descriptions of 'simple' polymers such as the excluded volume or scaling theory. Rather, these studies show that its biological response is coupled to the specific physico-chemical attributes of its segments and hence, to the competitive interactions between the solvent and other entities such as non-polar groups on the protein surface for the chain segments.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Sheth, Shailesh Rameshchandra

Contributors dc:contributor

• Deborah Leckband

• Chemistry, Physical

Language dc:language

eng

Identifier

(MiAaPQ)AAI9953136

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82474