Modeling and Simulation of Antisolvent Crystallization: Mixing and Control

This dissertation presents the development of simulation tools to address the issues of mixing and control in antisolvent crystallization processes, and to aid the development of systematic and scientific design approaches. The first part presents the development of an algorithm that couples macromixing and micromixing models with the population balance equation. It was applied to simulate antisolvent crystallization in a semibatch stirred vessel and an impinging jet crystallizer. The effects of the operational variables on the crystal size distribution and polymorphic form were numerically investigated. The second part focuses on the theoretical development and analysis of control strategies applied to antisolvent crystallization processes. For semibatch crystallization, the advantage of concentration control over specification of antisolvent addition rate was demonstrated by sensitivity analysis to process disturbances. For impinging jet crystallizers, it is shown that, by coupling with an aging vessel with controlled growth, specific crystal size distributions can be tailored.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical and Biomolecular Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Woo, Xing Yi

Contributors dc:contributor

• Braatz, Richard D.
• Reginald B.H.Tan

• Engineering, Chemical

Language dc:language

eng

Identifier

(MiAaPQ)AAI3290431

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82399