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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"antisolvent"”.
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Antisolvent crystallisation in oscillatory baffled platforms
… attained that would otherwise be unattainable. Antisolvent crystallisation is a widely used method of crystallisation in both academia and industry. It is employed to crystallise compounds that are not amenable to other techniques such as cooling crystallisation and can be utilised to produce …
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Stochastic modeling of nonisothermal antisolvent crystallization processes
In this Thesis a stochastic approach to model antisolvent crystallization processes is addressed. The motivations to choice a stochastic approach instead of a population balance modeling has been developed to find a simple and an alternative way to describe the evolution of the Crystal Size …
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Optimal Control of Antisolvent and Cooling Crystallization
… process of feeding seeds produced by real-time antisolvent crystallization to cooling tank to decouple nucleation and growth. Optimization of the temperature profiles to achieve targeted crystal size distributions was presented as well. The overall contribution of the thesis is the development …
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Antisolvent gibbsite crystallisation from synthetic Bayer liquor
… the effectiveness of using water as an antisolvent to increase the overall gibbsite yield and the associated particle behaviours under isothermal conditions. The experiments were performed in a series of batch experiments which were divided into two subsets. Firstly, the effect of …
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Crystal Engineering In Antisolvent Crystallization Of Neodymium Sulfate
Antisolvent crystallization is a separation technology that separates a solute from the solvent by the addition of another solvent, in which the solute is sparingly soluble. High yields are achieved by using higher antisolvent-to-solvent ratios, but this generates higher supersaturation, which …
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Modeling and Simulation of Antisolvent Crystallization: Mixing and Control
… to address the issues of mixing and control in antisolvent crystallization processes, and to aid the development of systematic and scientific design approaches. The first part presents the development of an algorithm that couples macromixing and micromixing models with the population balance …
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Characterisation of turbulent mixing and its influence on antisolvent crystallisation
… it can control product quality and distribution. Antisolvent crystallisation is one such process which is strongly influenced by mixing. The initial mixing controls the distribution of supersaturation which in turn controls the nucleation rate and hence many key parameters such a particle size …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
… of desired size (between 1 and 5 ?m) through antisolvent crystallization in the presence of surfactants and polymeric additives. Salbutamol sulphate (SS) was used as the model drug compound. Several candidate antisolvents were screened via studying particle morphology, particle size and …
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Nucleation mechanism of crystal formation during antisolvent or cooling induced crystallisation
… nucleation mechanism of crystal formation during antisolvent or cooling crystallisation of simple amino acids: D,L-valine and glycine. These amino acids can co-precipitate with proteins to form Protein Coated Microcrystals (PCMCs) in which the crystals create a solid support and the …
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Precipitation of ultrafine particles using liquid antisolvent with concentric ultrasonic nozzle and subcritical CO2
… water soluble. Two processes namely, liquid antisolvent precipitation using ultrasonic nozzle and other process using subcritical CO_2 have been used to produce ultrafine particles of this drug. In liquid antisolvent precipitation, a combination of ultrasound, polymer and surfactant is used …
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Measurement of binary phase equilibria and ternary/quaternary gas antisolvent (GAS) system measurement and analysis
… for various GXL systems. The CO2 acts as an antisolvent in what is commonly known as a gaseous antisolvent (GAS) system. Essentially, this work shows that expansion of the tested solvents with CO2 will cause the precipitation of the solid solute. This work also analyzes the affect two solutes …
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Sodium Fluoride Hopper Crystals
… of an aqueous solution of sodium fluoride to an antisolvent method using ethanol. Key variables in the preparation of these crystals included the amount of water present in the antisolvent, the ratio of salt solution to antisolvent and the rate of stirring. The dissolution of these high surface …
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A thermodynamic framework for the modeling and optimization of crystallization processes
… into account temperature, seeding variables, and antisolvent feed rates. In addition, this framework takes into account the recent proliferation of predictive thermodynamic solubility models. These solubility models have the potential to greatly reduce the need for experimental data, thus, …
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Synthesis of CsPbBr3 Quantum Dots for Photodetectors
… by varying the amount of precursor injected into antisolvent, ligands in precursor or antisolvent, and centrifugation speed. Besides, we have fabricated the conventional sandwich structure photodiode by using CsPbBr3 QDs blended with conjugated polymer …
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Study of nucleation mechanisms and rational design of small-scale continuous crystallizers
… handling. When optimizing this design with antisolvent crystallization, it was discovered that crystallization kinetic parameters are affected by antisolvent composition independent from supersaturation levels. This thesis highlights, for the first time, that optimizing continuous …
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Crystalization studies in hollow fiber devices
… currently only by impinging jet mixers for antisolvent crystallization. Porous hollow fiber devices proved efficient mixing devices, which unlike other tubular devices offer the opportunity for substantial radial mixing and hence the production of good micromixing. By proper rating they can …
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Multiscale Modeling and Mechanistic Analysis of Crystallization and Particulate Processes
… in explaining how solvation dynamics trigger antisolvent crystallization and oiling-out, how reaction kinetics govern the structural evolution of metal- and covalent-organic frameworks (MOFs and COFs) under dynamic conditions, and how particle breakage can be modeled efficiently for process …
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Supercritical fluid spray processes for microencapsulation and formation of submicron aqueous dispersions of pharmaceutical compounds
Precipitation with a Compressed Fluid Antisolvent (PCA) and Rapid Expansion from Supercritical Solution (RESS) are two processes based on supercritical fluids that are capable of producing submicron particles. Novel variations of these basic processes have been examined to produce stable particles …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… prednisolone and budesonide). Arrested antisolvent nanoprecipitation using ethanol (solvent) and water (antisolvent) was conducted within the microreactors. To enable experimental design for the microreactor studies, solubility profiles in different ethanol-water combinations at 25 °C …
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Precipitation of micro/nanoparticles in enhanced high energy dissipation mixing systems
… in acetone using an aqueous solution as the antisolvent. Precipitation studies were conducted to determine the role on crystal size distribution of different operating parameters, such as impinging jet velocity, angle of impingement, sonication power, and the presence of different …
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