Cognitive Differentiation of Schizophrenia and Depression

An ERP study of sensory and working memory was designed to avoid confounding MMN with other components. Schizophrenics, depressives, and controls performed a tone discrimination task, in which subjects counted or ignored tones. Evidence of memory abnormalities emerged as a function of diagnosis and stimulus sequence. All three groups showed intact auditory sensory memory, with comparable amplitudes and sequence effects. Schizophrenics did not differ from controls overall, but, in analyses as a function of diagnostic subtype, MMN was reduced in paranoid schizophrenics. Depressives showed dysfunctional working memory, as indexed by exaggerated N2b. Schizophrenics did not differ from controls overall, but, in analyses as a function of diagnostic subtype, N2b for was nonsignificantly higher in negative-symptom schizophrenics, who most resemble depressives. Results suggest that in certain MMN paradigms which removed stimulus confounds, schizophrenics can produce an normal MMN, which is appropriately influenced by preceding stimulus sequence. In addition, results suggest abnormal voluntary, strategy-sensitive processing in psychopathology, particularly in patients showing negative symptoms.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Keller, Jennifer

Contributors dc:contributor

• Miller, Gregory A.

• Psychology, Clinical

Language dc:language

eng

Identifier

(MiAaPQ)AAI9953062

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/82290