University of Illinois at Urbana-Champaign
Localization of Small-Nuclear-Rna Genes of Drosophila Melanogaster on Polytene Chromosomes
Abstract
dc:descriptionThe existence of discrete, stable, small nuclear RNAs (snRNAs) is known since 1960s. These RNAs range in size from 90-300 nucleotides and are confined to eukaryotic nuclei. snRNAs have been well-characterized biochemically and have been isolated and sequenced from different organisms. Recent observations that these RNAs associate with hnRNA and small nuclear ribonucleoproteins (snRNPs) act as antigens that are precipitated by antibodies from patients with lupus erythematosus, an auto-immune rheumatic disease, have sparked new interest in these molecules. snRNAs have been found to be highly conserved in evolution and certain regions of these RNAs show complementarity to intron/exon splice junctions. This has led to the suggestion that snRNAs act as mediators in mRNA processing. However, there is no direct evidence.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Genetics and Development
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Nag, Abhijit
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8203539
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/77613