Structural and Functional Requirements for Homotypic and Heterotypic Interference by Indiana Serotype Defective Interfering Particles of Vesicular Stomatitis Virus

Ultraviolet light inactivation of Indiana serotype vesicular stomatitis virus and four defective interfering (DI) particles was measured to determine the target size for interference. In the case of DI particles whose genomes mapped at the 5' end of the virion RNA, this target size corresponded to the entire DI particle RNA molecule regardless of whether it amounted to 10%, 30%, or 50% of the viral genome. These data were interpreted as demonstrating that both termini of the DI particle RNAs were required for their replication and for interference with virion RNA replication.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Bay, Pauline Hsiao Sing

• Biology, General

Language dc:language

eng

Identifier

(UMI)AAI8203402

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/77580