Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"RNA replication"”.
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In Vitro Studies of Viral Rna Replication
Made available in DSpace on 2014-12-09T22:04:17Z (GMT). No. of bitstreams: 1 6801824.pdf: 3616523 bytes, checksum: f87239971fd149ef4b618b9ef8e9fae3 (MD5) Previous issue date: 1967
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Studies of the Intermediates in Viral Rna Replication
Made available in DSpace on 2014-12-09T22:04:19Z (GMT). No. of bitstreams: 1 6910730.pdf: 3631190 bytes, checksum: 2f37bfb90a50d0ceecba65806ad9e004 (MD5) Previous issue date: 1968
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
… of specialized domains harboring viral replication complexes, called replication organelles. The cellular protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) is essential for the replication of enteroviruses, but its molecular role in the replication …
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In Vitro Experiments on the Specificity of Viral Rna Replication
Made available in DSpace on 2014-12-11T00:00:12Z (GMT). No. of bitstreams: 1 7105170.pdf: 5614570 bytes, checksum: 5c746d2e25ba9a02fe30c4d5d6023bb8 (MD5) Previous issue date: 1970
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GCD10 and GCD14 Proteins Facilitate Tomato Bushy Stunt Viral (TBSV) RNA Replication in Saccharomyces Cerevisiae
… bushy stunt virus (TBSV) is a positive-sense RNA virus and its genome replication requires two viral proteins, p33 and RNA-dependent RNA polymerase p92. Previous studies showed that the 5 untranslated region (5UTR) of the genome is important, albeit not essential, for viral RNA replication in …
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RNA replication by poliovirus RNA-dependent RNA polymerase: effects of residue 5 on elongation complex stability and processivity
The poliovirus (PV) RNA-dependent RNA polymerase (RdRP) is a small, single-subunit, enzyme that is responsible for the replication of the viral genome. PV genome replication is much more involved than just repetitively incorporating a single nucleotide into an oligonucleotide primer. The polymerase …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the impact organelle membrane targeting through protein prenylation has on the antiviral …
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Studies on the replication of hepadnaviruses and hepatitis delta virus / Tom Bernard Macnaughton.
Examines hepadravirus and HDV replication and gene expression with particular emphasis on the block(s) preventing HBV infection invitro, the extent of the helper function provided by HDV by HBV and the mechanism of HDV RNA replication.
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Progress Towards Integrated Models of HCV Dynamics
… C virus is a small, enveloped positive-strand RNA member of the Flaviviridae and the etiological agent of a global epidemic of chronic hepatitis C. One of the salient features of HCV is a complex regulatory scheme involving numerous viral and cellular components and which may be the key to its …
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Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model
… to IAV infection but this results abortive replication, following established understandings. However, MPI macrophages are much more sensitive to influenza infection than non-AM models, resulting in a greater pro-inflammatory cytokine, chemokine, and type I IFN responses. This sensitivity 8 …
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Structural and Functional Requirements for Homotypic and Heterotypic Interference by Indiana Serotype Defective Interfering Particles of Vesicular Stomatitis Virus
… whose genomes mapped at the 5' end of the virion RNA, this target size corresponded to the entire DI particle RNA molecule regardless of whether it amounted to 10%, 30%, or 50% of the viral genome. These data were interpreted as demonstrating that both termini of the DI particle RNAs were required …
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Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… superinfection, at the levels of virus entry and RNA replication. The former is mediated by the BVDV E2 protein, which was also identified as a transdominant inhibitor of BVDV entry in a screen of a random fragment BVDV cDNA library. The inhibitory region was further mapped to the E2 ectodomain …
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The contribution of viral and host cell factors to replication of the hepatitis C virus RNA genome
… the development of in vitro systems that permit replication of the viral RNA genome and virus particle production. However, the exact functions of the viral proteins, particularly those engaged in RNA synthesis, are poorly understood. It is thought that NS4B, one of the replicase components, …
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FUNCTIONAL CHARACTERIZATION OF PAPAIN-LIKE PROTEASE p48 REQUIRED FOR REPLICATION OF HYPOVIRUS CHV-1 RESPONSIBLE FOR VIRULENCE-ATTENTUATION OF THE CHESTNUT BLIGHT FUNGUS
… has been shown to be dispensable for hypovirus RNA replication, whereas protease p48 is essential for hypovirus RNA replication. The p48 protein can also act <italic> in trans </italic> to complement a mutant CHV-1/EP713, p48 deficient virus (δp48). The δp48 mutant virus retained …
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
… severity to understand the role of NS1 in virus replication and disease pathogenesis. The T164S mutant virus (TS-virus) infection resulted in reduced virus production and increased sNS1 production in various cell lines and human PBMCs without affecting viral-RNA replication. Infection of AG129 …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… (IFN)-based therapy. The development of the HCV RNA replicon system has allowed the study of persistent HCV RNA replication in tissue culture. We evaluated HCV/IFN interactions within a long-term culture system of Huh7 cell lines harboring different variants of an HCV genotype 1b subgenomic RNA …
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Investigation of the Polyprimidine Tract-Binding Protein-Associated Splicing Factor (PSF) Domains Required for the Hepatitis Delta Virus (HDV) Replication
… composed of ~1,700nt, is the smallest circular RNA pathogen known to infect humans. Understanding the mode of replication of HDV implies on investigating the host proteins that bind to its genome. The polypyrimidine tract-binding protein-associated splicing factor (PSF), an HDV interacting …
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Coronavirus Replication Inhibition by Herbal Extracts
Coronaviruses are plus-stranded RNA viruses that infect human and large variety of animals, including pig, cattle, dog, rat, rabbit, turkey, and bird. Human coronavirus has been known to cause common colds and perhaps gastroenteritis. Animal coronaviruses cause gastroenteritis, hepatitis, and a …
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