Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles

Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Lai, Mei-Hsiu

Contributors dc:contributor

• Kong, Hyun Joon
• Murphy, Catherine J.
• Schroeder, Charles M.
• Zhao, Huimin

• polyaspartamide
• near-infrared (NIR) fluorescence imaging
• enhanced permeability and retention (EPR) effect
• polymeric vesicles (polymersomes)
• polymeric micelles
• surface plasmon resonance (SPR) spectroscopy

Statement dc:rights

• Copyright 2014 Mei Lai

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/73039

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/73039