{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/73039"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/73039","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles","abstract":"Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.","abstract_html":"Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.","abstract_has_math":false,"creators":["Lai, Mei-Hsiu"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Kong, Hyun Joon","Murphy, Catherine J.","Schroeder, Charles M.","Zhao, Huimin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-01-21T19:58:45Z","date_published":"2015-01-21T19:58:45Z","updated_at":"2026-07-22T22:26:07Z","subjects":["polyaspartamide","near-infrared (NIR) fluorescence imaging","enhanced permeability and retention (EPR) effect","polymeric vesicles (polymersomes)","polymeric micelles","surface plasmon resonance (SPR) spectroscopy"],"languages":["en"],"rights":["Copyright 2014 Mei Lai"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/73039","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kong, Hyun Joon","Murphy, Catherine J.","Schroeder, Charles M.","Zhao, Huimin"]},{"key":"dc:creator","label":"Author","values":["Lai, Mei-Hsiu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-01-21T19:58:45Z","2017-01-22T10:15:30Z","2014-12","2015-01-21"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["polyaspartamide","near-infrared (NIR) fluorescence imaging","enhanced permeability and retention (EPR) effect","polymeric vesicles (polymersomes)","polymeric micelles","surface plasmon resonance (SPR) spectroscopy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2014 Mei Lai"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/73039"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.","Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-10-17T15:43:26Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lai_MeiHsiu.pdf: 3601767 bytes, checksum: 72b5b6487c284cdbf1222133d426e462 (MD5)","Made available in DSpace on 2015-01-21T19:58:45Z (GMT). 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Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.","Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-10-17T15:43:26Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lai_MeiHsiu.pdf: 3601767 bytes, checksum: 72b5b6487c284cdbf1222133d426e462 (MD5)","Made available in DSpace on 2015-01-21T19:58:45Z (GMT). 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