Skeletal Muscle Energetics and Mechanics: The Effects of Magnesium on Resting and Contracting Muscle as Studied by Phosphorus Magnetic Resonance Spectroscopy

Although much is known about the role of calcium in skeletal muscle mechanics and energetics, little is known about the role of magnesium, especially in intact muscle. This work studies skeletal muscle energetics and mechanics using MR spectroscopy (MRS) with particular reference to the role of magnesium. The accuracy and precision of $\sp{31}$P MRS as a technique for this study was evaluated. A servocontrol system was implemented such that isolated frog skeletal muscles could be made to undergo various isometric or isotonic contractions during acquisition of $\sp{31}$P MRS data. Frog muscles were studied in various temperature and bathing solution environments, and the spectroscopic changes were related to ion flux, metabolic inhibition, and the contractile properties of the muscle.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Physiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Roman, Brian Bernard

Contributors dc:contributor

• Dawson, M. Joan

• Chemistry, Biochemistry
• Biophysics, General
• Applied Mechanics
• Biology, Animal Physiology

Identifier

(UMI)AAI9305669

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/72567