The Role of Humoral Immunity in The Resolution of Rotavirus Infection in Mice

The immune response to rotaviruses has been studied extensively in several animal species. However, the importance of a humoral immune response in the resolution of active rotavirus infection has not been investigated directly. Most animals became resistant to rotavirus-induced diarrhea after a certain age. The study of host factors, such as the intestinal antibody response, involved in the resolution of virus infection in the neonate may shed light on the mechanisms of age-dependent resistance to disease. The mouse offers a unique opportunity to study the role of virus-specific intestinal antibodies in resolution because most, if not all, antibodies in the neonatal intestine during the course of infection are passively acquired in milk via suckling.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Medical Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Patterson, Jon Scott

• Health Sciences, Pathology

Identifier

(UMI)AAI8721733

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/71345