Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Humoral Immunity"”.
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Bruton's tyrosine kinase regulator of innate and humoral immunity
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Genetics and Evolution of Drosophila Humoral Immunity against Parasitoid Infections
… However, the regulation of Drosophila humoral immunity against parasitoids is not clearly illustrated. In this thesis, I investigated the humoral immune mechanisms underlying Drosophila resistance to parasitoid infections, as well as the evolution of humoral immunity in populations that …
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Modulation of humoral immunity in the rat by 17beta-estradiol and prolactin
… prolactin (PRL) and estradiol (E$\sb2$) augment immunity. Given that E$\sb2$ is a potent physiologic stimulus for the release of PRL from the pituitary, it is plausible that PRL mediates the influence of E$\sb2$ upon the immune system. To test this hypothesis, we conducted four experiments.
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Methods, Models, and Machine Learning Approaches for Understanding Pathogen-Specific Humoral Immunity
The humoral immune response is comprised of vast libraries of polyclonal antibodies capable of recognizing a myriad of targets and directing a spectrum of innate immune functions. The complex heterogeneity in antibody profiles across both populations and diseases makes defining mechanisms of …
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The Role of Humoral Immunity in The Resolution of Rotavirus Infection in Mice
… animal species. However, the importance of a humoral immune response in the resolution of active rotavirus infection has not been investigated directly. Most animals became resistant to rotavirus-induced diarrhea after a certain age. The study of host factors, such as the intestinal antibody …
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The role of the thymus in the enhancement of humoral immunity by estrogen
… have observed that estrogen enhances humoral immune responsiveness. The goal of this thesis has been to establish a physiological in vivo model in which to study this phenomenon and to characterize the role of the thymus as its mediator. An immunizing dose of 0.25 mg fluorescein …
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Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses
… Some of these changes are recognised by the humoral system and are known as Tumour Associated Antigens (TAA) against which the humoral system is able to mount an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the "2-hit" hypothesis …
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Extent of genotype-specific humoral immunity produced on infection with hepatitis C virus: relevance for serological screening and diagnosis
… type-specific and type-common components of the humoral immune response were investigated by measuring the antibody levels in samples of each genotype with type-homologous and type-heterologous antigens. Reactivity directed against the individual genotype 1 antigens used in a commercially …
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Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response
… was to determine if divergent selection for humoral immune response would have an impact on the ability of the chicken to cope with gossypol toxicosis. Two preliminary studies were conducted. One determined basal activities of liver detoxification enzymes at various ages. The other determined …
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… importance of CD28 in initiating protective Th2 immunity against both primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of CD28 …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… (e.g., HIV) and tumors require functional CTL immunity and are ineffectively treated by antibodies or humoral immunity. Traditional needle-based vaccination strategies primarily induce humoral immunity and are inefficient at eliciting robust CTL responses using subunit or whole protein …
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An evaluation of novel lipid-enveloped nanoparticles for adjuvant and antigen delivery for an HIV vaccine : stepping from laboratory into potential markets
… of the antigen on their surfaces and to elicit humoral immunity response. Topics such as patent ability, obtaining an FDA licensure, storage, cost of manufacturing, and supply of the vaccine are explored. A business model for commercialization of the vaccine is outlined, and some possible future …
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TRIM21 Mediated Antibody-Dependent Intracellular Immunity
… 1890s, revealing their importance in protective immunity and allowing their development in numerous research and therapeutic applications. However, these studies have focused almost exclusively on the extracellular effector mechanisms of antibodies such as opsonisation, complement activation, …
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… HIV are complex and involve both cellular and humoral immunity. Based on the recent finding that the best correlate of protection against the first protective prophylactic RV144 vaccine were HIV-specific antibody responses, including those mediating natural killer (NK) cell antibody-dependent …
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A Study of Slime-Positive Coagulase-Negative Staphylococci
… webster mice with no implanted medical device. Humoral immunity to CNS slime was studied and it was found that New Zealand white rabbits were unable to mount an antibody response to slime. A slime quantitation procedure was developed that utilizes spectroscopy. The effect of glucose …
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The use of whole blood cell cultures as a model for assessing the effects of SeptilinTM on the immune system.
… IL-10, and IFN? as biomarkers for inflammation, humoral immunity, and cell mediated immunity, respectively. Results show that the presence of SeptilinTM in LPS stimulated WBC has no effect on the release of IL-6 and IFN? production but stimulated IL-10 production. SeptilinTM in unstimulated WBC …
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Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer
… indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic relationship to TNF-¿¿. Health anxiety was unrelated to inflammation. High levels of anxiety and worry may be related to a shift away from …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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Investigation of dendritic cells as a vector for vaccine delivery
… to reveal arole for both cell-mediated and humoral immunity in protection against <i>B. pseudomallei</i> infection. The data also demonstrate the potential for DC as vaccine delivery vectors and as a screening mechanism for the evaluation of potential vaccine candidates.
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Clinical and immunological factors associated with post-race upper respiratory tract symptoms (URTS) in Ironman triathletes
… a TH1 response (IL-2, and IL-12) (cell mediated immunity) and a TH2 response (IL-4, IL-6, IL-10) (humoral immunity), as well as a saliva sample (for salivary α-amylase, cortisol and IgA concentrations). Collection of blood and saliva samples was repeated immediately post-race. Data regarding race …
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