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University of Illinois at Urbana-Champaign
Structure, Function, and Diversity of Monoclonal Anti-Fluorescyl Antibodies
Abstract
dc:descriptionThe structural basis of antibody affinity and the mechanism by which IgG antibodies undergo increases in affinity with time (maturation) during the immune response were examined using a fluorescein hapten system in conjunction with hybridoma methodology. Monoclonal anti-fluorescyl IgG antibodies (nine clones) were produced by fusion of BALB/c splenocytes and Sp 2/O-Ag 14 myeloma cells. Analyses of these clones were performed in order to compare structure/function relationships and to determine their prevalance in heterogeneous BALB/c immune sera.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Microbiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Kranz, David Michael
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8302912
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/71155