Methods Development in Chiral Chromatography

Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Mahler, George Stephen

• Chemistry, Organic

Identifier

(UMI)AAI8701556

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70350