{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/70350"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/70350","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Methods Development in Chiral Chromatography","abstract":"Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.","abstract_html":"Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.","abstract_has_math":false,"creators":["Mahler, George Stephen"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-15T23:18:51Z","date_published":"2014-12-15T23:18:51Z","updated_at":"2026-07-22T22:26:02Z","subjects":["Chemistry, Organic"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8701556"],"render_values":[{"text":"(UMI)AAI8701556","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/70350","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mahler, George Stephen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-15T23:18:51Z","10000-01-01","1986"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/70350","(UMI)AAI8701556"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.","The use of N-3,5-dinitrobenzoyl-R-phenylglycine as a classical resolving agent for the resolution of several amines by formation of diastereomeric salts of differing solubilities is also considered.","Made available in DSpace on 2014-12-15T23:18:51Z (GMT). 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In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed.","The use of N-3,5-dinitrobenzoyl-R-phenylglycine as a classical resolving agent for the resolution of several amines by formation of diastereomeric salts of differing solubilities is also considered.","Made available in DSpace on 2014-12-15T23:18:51Z (GMT). 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