Part 1. Biologically Active Compounds From Agelas Sponges. Part 2. Barnacle Settlement Inhibitors From Octocorallia (Antifouling, Antibacterial, Renillafoulins, Antiviral, Caribbean)

Biologically active extracts of the Caribbean sponges Agelas coniferin and Agelas cf. mauritiana have been found to contain seven new bromopyrroles (1a, 3a-8a), as well as the known debromooroidin-dimer sceptrin (2a). These compounds, isolated as the diacetate salts, were found to be antibacterial and antiviral, and were active in barnacle settlement and biochemical prophage induction assays. The structures, with tentative stereochemistries, were based on spectroscopic comparisons to sceptrin (2a) and two-dimensional NMR data.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Keifer, Paul Allen

• Chemistry, Organic

Identifier

(UMI)AAI8701527

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70347