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Showing 1 to 20 of 44 for “"prophage"”.
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Genetic Functions of Prophage: Interference With the Multiplication of Heterologous Bacteriophages
Made available in DSpace on 2014-12-05T21:45:25Z (GMT). No. of bitstreams: 1 0015236.pdf: 3975538 bytes, checksum: 5088a54a43f0def1f5fa218c36ae6270 (MD5) Previous issue date: 1955
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Transposable prophage Mu exists as an independent chromosomal domain in E. coli
… DNA-binding proteins. We find that transposable prophage Mu, transcriptionally silent by definition, is organized into an independent domain as determined by the close proximity of Mu termini L and R separated by a 37 kb Mu genome. Cre-loxP recombination is used in this study in vivo and in …
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The effect of active prophage carriage on the virulence of Pseudomonas aeruginosa
… phages integrated into the LES genome as active prophages, which provide fitness advantages, but can also be induced to their replicative form and destroy their host by lysis. Active phages are very common in the CF lung and infecting P. aeruginosa strains commonly carry many prophages, but …
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Physiological roles and regulation of the cryptic prophage-encoded small protein DicB and small RNA DicF in Escherichia coli
… been characterized, very few that are phage or prophage-encoded have been studied. This dissertation describes the roles and regulation of the sRNA DicF and small protein DicB encoded on the Qin cryptic prophage of Escherichia coli K12. Bacterial genomes harbor cryptic prophages that have lost …
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Characterization of novel prophages in lysogenic murine isolate lactobacillus murinus EF-1
We sought to isolate and characterize prophage from an inducible lysogenic Lactobacilli host from a rat gastrointestinal tract. First we isolated a Lactobacillus murinus strain from a rat fecal sample. After initial antibiotic induction, high-throughput DNA sequencing and assembly identified the …
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The Genomic Sequence and Annotation of Bacteriophage HK239
… its genome into the host chromosome, creating a prophage. The cell containing the prophage is known as a lysogen. Most prophage genes are not expressed. However, those that are encode a wide variety of functions. One function is exclusion, or the prevention of a different phage type from …
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Part 1. Biologically Active Compounds From Agelas Sponges. Part 2. Barnacle Settlement Inhibitors From Octocorallia (Antifouling, Antibacterial, Renillafoulins, Antiviral, Caribbean)
… active in barnacle settlement and biochemical prophage induction assays. The structures, with tentative stereochemistries, were based on spectroscopic comparisons to sceptrin (2a) and two-dimensional NMR data.
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The ecology of prophages at the microscale
… both taxonomically and functionally, with prophage induction, especially among founding community members, emerging as one factor significantly associated with this variability. However, the ecological modulators of lysogeny-lysis transitions in complex communities remain largely unknown. …
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Bacteriophages in the honey bee gut and amphibian skin microbiomes: investigating the interactions between phages and their bacterial hosts
… or integrate into the bacterial genome as a prophage. As a prophage, the phage may alter bacterial host phenotypes by carrying novel genes associated with auxiliary metabolic functions, virulence-enhancing toxins, or resistance to other phage infections. Lytic phages may also carry certain …
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A genetic analysis of bacteriophage lambda integrase-core site interactions
… the host target sequence, attB to generate the prophage sites, attL and attR. attP contains the core region, where strand exchange occurs, and the required flanking sequences, the P and P$\sp\prime$ arms. Within the core, there are two Int core-type binding sites. The flanking arm sequences …
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The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
… in elucidating novel ways in which the prophage influence GrAS virulence and survival either within the host cell or within the bacterial population. In turn, we also hoped to determine how the bacteria (and possibly other integrated phage) might influence prophage activity or gene …
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The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage
… thesis explores the potential role of integrated prophage on the streptococcal transcriptome. We are specifically interested in global regulatory systems in group A streptococci and how they impact virulence regulation. With this work, we hoped to identify new regulatory elements involved in the …
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Role of the Small Terminase Subunit Encoded by Staphylococcus Aureus Pathogenicity Island SaPI1 in Formation of SaPI1 Transducing Particles
… the small terminase genes in SaPI1 and in a prophage copy of 80α are consistent with this hypothesis. Induction of the 80α small terminase deletion mutant produces wild type levels of SaPI1 transducing particles, demonstrating that SaPI1 small terminase can replace that of 80a in SaPI1 …
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Characterisation of the temperate bacteriophages of salmonella enterica and salmonella bongori
… has been suggested that a variable assortment of prophages provides a transferable repertoire of pathogenic determinants in Salmonella. The temperate phages present in Salmonella enterica serovar Typhimurium isolates have been most extensively investigated to date. However, how variable is the …
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A streamlined Workflow for Transposon Mutagenesis in Corynebacterium glutamicum Based on Third-Generation Sequencing and its Application for Advanced Genetic Screens
… the establishment and utilization of the prophage- and insertion sequence(IS)-free *Corynebacterium glutamicum* platform strain CR101 for an efficient integration system, a transposon mutagenesis system based on the endogenous IS*Cg1* transposase and a streamlined workflow for transposon …
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Hypermutation and adaptation of experimentally evolved marine Vibrio bacteria
… with a deletion resulting from improper prophage excision. Members of this family of prophages are found in other proteobacteria, including well-studied human pathogens, from very different environments. Mutators are known to arise spontaneously in wild and clinical bacteria, but the …
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Identification and Characterization of Helper Phage Gene Products Involved in Mobilization of Staphylococcal Pathogenicity Island SaPI1
… of each candidate gene was constructed in an 80α prophage. All mutant phage and deletion constructs were evaluated for phage replication, SaPI1 replication, SaPIl transduction and SaPI1 interference. One gene (ORF21) was required for 80α growth and replication, but was not required for SaPIl …
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Gene transfer agents promote survival and DNA repair during stationary phase for Caulobacter crescentus
Gene transfer agents (GTAs) are prophage-like entities found in many bacterial genomes that cannot propagate themselves and instead package ~5-15 kbp fragments of the host genome that can then be transferred to related recipient cells. Although suggested to facilitate horizontal gene transfer in …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… genes were found to be associated with prophage-like sequences, plasmids, and/or transposons. Therefore, it is likely that these mobile genetic elements played a significant role in creating genomic diversity and phenotypic variability among strains of H. somni. Functional …
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Microbial Growth On Anthropogenic Compounds By Reductive Dehalogenation Or Oxidation
… producing ethene. Its genome contains a putative prophage, which could inhibit its ability to grow to high densities and cause phage mediated cell death. This phage was evaluated by genomic comparisons and electron microscopy. Cellular stress induced phage expression and stopped dechlorination. …
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