Biologically Active Compounds From Caribbean Sponges

The isolation and structure elucidation of a number of 1,2-dioxolane and 1,2 dioxane acids and esters from two caribbean sponges is described. Interest in these compounds was motivated by the acid's pharmacological activities when tested in vitro against various gram positive bacteria, yeasts and fungi. The corresponding esters were relatively inactive as antibacterial agents but because they were more stable and easier to purify, they were the compounds chosen for the structural studies. Structure elucidation of the purified esters was based on interpretation of the compounds high resolution nuclear magnetic resonance and mass spectra. Confirmation of some of the structures was accomplished by an ozonolysis degradation sequence and formation of a lactone from the ester carbonyl and one of the peroxide oxygens and spectroscopic characterization of the derivatives.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Phillipson, Douglas Wayne

• Chemistry, Organic

Identifier

(UMI)AAI8511660

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70294