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University of Illinois at Urbana-Champaign
1-Acylamido boronic acids and Difluoroborane analogs of amino acids: Synthesis and biological activity of transition state analogs for Chymotrypsin and Elastase (inhibition, esters)
Abstract
dc:description"Several acylamido boronic acids and difluoroborane analogs of amino acids, some as single enantiomers, have been synthesized and evaluated as ""transition state"" inhibitors of the serine proteases (alpha)-chymotrypsin and elastase. These inhibitors were designed to resemble N-acyl phenylalanine, phenylglycine (as chymotrypsin inhibitors), alanine, valine, and isoleucine (as elastase inhibitors) and have boron sybstituted for the carboxy terminus carbon. Acyl groups were benzoyl, benzyloxycarbonyl-alanyl (Z-alanyl) and Z-glycinyl."
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Kinder, David Harold
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8422102
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/70252