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University of Illinois at Urbana-Champaign
Polyandrocarpidines: Antimicrobial and Cytotoxic Compounds From the Marine Tunicate Polyandrocarpa Sp
Abstract
dc:descriptionThe marine tunicate Polyandrocarpa sp. contains anti-microbial and cytotoxic metabolites, polyandrocarpidines, whose structures include a polymethylenediamine chain; one nitrogen is acylated with a twelve-carbon fatty acid which contains a cyclopropene ring in conjugation with a diene system, the other nitrogen is part of a primary guanidine function. It was advantageous to convert the guanidine to the dimethylpyrimidyl moiety by condensing with 2,4-pentanedione in the presence of sodium bicarbonate, because the dimethylpyrimidyl derivatives can be gas chromatographed, and the dimethylpyrimidyl moiety institutes very characteristic mass spectrometric fragmentations for the rest of the molecule.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Cheng, Michael Tung-Hai
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8108462
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/67237