Bioparticle capture and sensing utilizing nanograss based microfluidic devices

For the past few decades, biosensors have been developed at a steady pace and played a crucial role in medical practices and many other biomedical applications. Upon performing a survey of desirable sensor properties such as low cost, high sensitivity, fabrication process, and time to result, a nanograss embedded microfluidic device emerged as a very attractive candidate for an electrochemical impedance spectroscopy (EIS) based biosensor. Such a sensing device is expected to perform direct sensing quickly with high sensitivity, and at low cost. In this work, the nanograss fabrication process is illustrated in detail. Then nanograss substrate itself is characterized by multiple approaches. In addition, COMSOL Multiphysics is used for finite element simulation of the flow through the microfluidic chamber. The EIS method is used to evaluate the capture and sensing ability of the fabricated nanograss embedded microfluidic device. The nanograss devices are shown to be able to capture and sense a few particles/µL, indicating that the nanograss devices could be used as next-generation biosensors.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Electrical & Computer Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2013

Author dc:creator

• Ni, Hengkan

Contributors dc:contributor

• Bashir, Rashid

• Nanograss
• Biosensor
• Electrochemical Impedance Sensing (EIS)

Statement dc:rights

• Copyright 2012 Hengkan Ni

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/42299

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/42299