Strategies for developing ultrathin, high-density, actively multiplexed neural mapping device

Electronic systems that integrate with biological systems must be able to accommodate the dynamic mechanical characteristics of the tissue. With the rise in the interest of diagnosing and treating brain diseases it is critical that electrodes involving brain/machine interfaces have minimal effect on the brain while ensuring conformal coverage and good signal quality. A two-stage attempt is described in this thesis, where technological advancement involved in the producing of an extremely conformal platform is described, followed by the introduction of a high-density, actively multiplexed, flexible, and foldable sensor array. Experimental data show that as substrate thickness decreased the signal quality increased. Thin mesh-type systems showed further improvements in electrode response. An array of ultrathin, highly dense silicon nanomembrane transistors was fabricated on flexible plastic substrates and recorded neural activity with high spatial resolution. Brain activities, such as sleep spindles, single-trial visual evoked responses, and electrographic seizures could be successfully recorded. Analysis of the recorded data reveals the propagation of the punctual spatial patterns composed of planar and spiral waves during epileptic stage.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Materials Science & Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2012

Author dc:creator

• Kim, Yun Soung

Contributors dc:contributor

• Rogers, John A.

• flexible
• neural
• ultrathin
• multiplexed
• silk

Statement dc:rights

• Copyright 2012 Yun Soung Kim

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/31108

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/31108