Instrumentation for a distributed feedback laser biosensor system

The development of the instrumentation behind a biosensor system based on a vertically emitting distributed feedback laser is presented. The performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug screenings. A series of filtering and averaging methods for minimizing the effects of sensor noise are discussed in the analysis of both single spectrum measurements and kinetic scans over time. An example biochemical assay is performed to demonstrate and evaluate the current capabilities of the biosensor system. Plans for the future advancement of the system, including the possibilities of hardware improvements, device fabrication refinements, data analysis enhancements, and new usage models, are considered.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Electrical & Computer Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Chu, Allen C.

Contributors dc:contributor

• Cunningham, Brian T.

• Distributed Feedback Laser
• Biosensor
• Instrumentation
• Biochemical Assay
• Label Free
• Biomolecular Detection
• Small Molecule Interaction

Statement dc:rights

• Copyright 2011 Allen C. Chu

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/26150

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/26150