{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/26150"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/26150","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Instrumentation for a distributed feedback laser biosensor system","abstract":"The development of the instrumentation behind a biosensor system based on a vertically emitting distributed feedback laser is presented. The performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug screenings. A series of filtering and averaging methods for minimizing the effects of sensor noise are discussed in the analysis of both single spectrum measurements and kinetic scans over time. An example biochemical assay is performed to demonstrate and evaluate the current capabilities of the biosensor system. Plans for the future advancement of the system, including the possibilities of hardware improvements, device fabrication refinements, data analysis enhancements, and new usage models, are considered.","abstract_html":"The development of the instrumentation behind a biosensor system based on a vertically emitting distributed feedback laser is presented. The performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug screenings. A series of filtering and averaging methods for minimizing the effects of sensor noise are discussed in the analysis of both single spectrum measurements and kinetic scans over time. An example biochemical assay is performed to demonstrate and evaluate the current capabilities of the biosensor system. Plans for the future advancement of the system, including the possibilities of hardware improvements, device fabrication refinements, data analysis enhancements, and new usage models, are considered.","abstract_has_math":false,"creators":["Chu, Allen C."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Cunningham, Brian T."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08-25T22:16:22Z","date_published":"2011-08-25T22:16:22Z","updated_at":"2026-07-22T22:25:26Z","subjects":["Distributed Feedback Laser","Biosensor","Instrumentation","Biochemical Assay","Label Free","Biomolecular Detection","Small Molecule Interaction"],"languages":["en"],"rights":["Copyright 2011 Allen C. 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