A mathematical model of the airway epithelium: Computational studies of ion and water balance

A mathematical model has been developed to investigate the time course of ion and water transport across airway epithelia. Model variables were intracellular and apical concentrations of sodium, potassium, chloride; apical, basolateral, and transepithelial membrane potentials; cell and apical volumes. Membrane transport processes included apical passive diffusion of sodium and chloride, basolateral passive diffusion of potassium, basolateral sodium-potassium active transport, basolateral sodium-potassium-chloride cotransport, water permeation across all membranes, and nonselective paracellular passive diffusion of sodium, potassium, and chloride. Initial conditions and transport parameters were derived from experimental results.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Novotny-Dura, Janet Anne

Contributors dc:contributor

• Jakobsson, Eric

• Biology, Animal Physiology
• Biophysics, General

Statement dc:rights

• Copyright 1993 Novotny-Dura, Janet Anne

Language dc:language

eng

Identifier

AAI9411735
(UMI)AAI9411735

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23405