Analyses and predictions of ultrasound interactions with model biomembrane systems via two-state transition model

Low intensity ultrasound (approximately 10$\sp{-6}$ W/cm$\sp2$) in the frequency range of 0.5 MHz to 5.0 MHz was employed to investigate biomembrane structural relaxation kinetics via absorption and velocity dispersion spectroscopy. The multilamellar vesicles utilized in this investigation were either composed of pure phospholipids or mixtures of phospholipids and small molar fractions of protein gramicidin. The experimental findings reveal enhanced ultrasound interactions near to the lipid phase transition temperature. The enhanced ultrasound absorption spectra closely resemble single relaxation spectra, suggesting that the membrane constituents undergo a simple two-state transition. The temperature dependence of the relaxation frequency is followed with the combined aid of the absorption and velocity dispersion spectrum. Thermodynamic and electrical capacitor two-state transition models are developed to help describe the observed phenomena and to predict to a reasonable degree of accuracy the enhanced findings promoted by ultrasound.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics and Computational Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Tata, Darayash Burjor

Contributors dc:contributor

• Dunn, Floyd

• Chemistry, Physical
• Engineering, Biomedical
• Physics, Acoustics

Statement dc:rights

• Copyright 1991 Tata, Darayash Burjor

Language dc:language

eng

Identifier

AAI9211009
(UMI)AAI9211009

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23330