Characterization of the IGF system in food-restricted pregnant and lactating rats: Role of IGF-I in nutrient partitioning

Metabolic and behavioral mechanisms have been implicated in the development of adaptive strategies to suboptimal nutrition. However, very little is known about the underlying endocrine mechanisms involved in this adaptation. To investigate the role of the IGF-I in adaptation to dietary restriction, the experiments reported herein determined the changes in the circulating levels, as well as, in the gene expression of IGF-I and IGFBPs in pregnant and lactating rats which were food restricted during pregnancy and lactation or solely during lactation. In addition, the effects of IGF-I administration on amino acid uptake was investigated using an alanine analogue.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Food Science and Human Nutrition

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Monaco, Marcia Helena

Contributors dc:contributor

• Donovan, Sharon M.

• Agriculture, Animal Culture and Nutrition
• Health Sciences, Nutrition

Statement dc:rights

• Copyright 1995 Monaco, Marcia Helena

Language dc:language

eng

Identifier

AAI9522152
(UMI)AAI9522152

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22886