Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 377 for “"IGF"”.
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A study on the interactions of synthetic IGF-II analogues with the type 1 IGF and insulin receptors.
Insulin-like growth factor II (IGF-II) is a unique regulatory peptide containing 67 residues and three disulfide bonds. It binds with high affinity to three receptors, the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF-1R) and the We 2 insulin-like growth factor receptor …
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Characterization of the IGF system in food-restricted pregnant and lactating rats: Role of IGF-I in nutrient partitioning
… this adaptation. To investigate the role of the IGF-I in adaptation to dietary restriction, the experiments reported herein determined the changes in the circulating levels, as well as, in the gene expression of IGF-I and IGFBPs in pregnant and lactating rats which were food restricted during …
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Intrauterine Wachstumsretardierung (IUGR) mit ARED-Flow in der Dopplersonographie der Arteria umbilicalis : molekulargenetische Analyse der Gene IGF-I und IGF-IR
… a possible role of mutations of the genes IGF-I (Insulin-like Growth Factor-I) and IGF-IR (Insulin-like Growth Factor-I Receptor) in the pathogenesis of intrauterine growth retardation/ restriction (IUGR) with ARED (Absent or Reversed EndDiastolic)-flow in the Doppler ultrasonography of the …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… between the endocrine and immune systems. IGF-I is a critical anabolic factor that promotes growth and regeneration of skeletal muscle. Conversely, elevated levels of proinflammatory cytokines are associated with reduced anabolic activity of IGF-I and increased loss of muscle mass that …
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Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
… in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show that there is a pH dependence in the association of IGF-I with the …
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Charakterisierung von Proteinen und Untersuchung des IGF-Systems im Eberseminalplasma
… und Hybridebergruppen einerseits Komponenten des IGF-Systems im Eberseminalplasma zu identifizieren und ihren Einfluss auf die Fertilität zu überprüfen, andererseits mittels der Proteomics-Technik das komplexe Proteingemisch im Eberseminalplasma zu analysieren. Es wurde das Vorhandensein von …
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Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster
… conserved nutrient-sensing Insulin/IGF-like signalling (IIS) pathway. IIS interacts with multiple cellular processes, including cell growth, development, metabolic homeostasis, fecundity and stress resistance. Evidence has revealed a strong connection between systemically reduced IIS …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… (IL-1beta) and interleukin-6 (IL-6), inhibit IGF-I-promoted DNA synthesis in human MCF-7 breast adenocarcinoma cells, T-47D breast ductal carcinoma cells, murine FDCP progenitor myeloid cells and human promyeloid HL-60 cells. Flow cytometry confirmed that all three cytokines suppress …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed …
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Untersuchungen zum Insulinbindungsbereich des Insulin-IGF-I-Rezeptorsystems mittels kovalenter Markierung
… region und stoichiometry of the insulin and the IGF-I receptor as well as of two chimeric insulin-IGF-I receptors. To achieve this two photoreactive insulin analogues, B29-Azidotetrafluorobenzoyl-biocytinyl-Insulin (B29-Atf-Bct-Insulin) and B29-Azidosalicyloyl-Insulin (B29-Asa-Insulin), were …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic malignancies and in the process of SV40-mediated malignant transformation of human cells. We have found that in SV40-transformed human mesothelial cells (HM) the Large T antigen (Tag), p53, pRb …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… by estrogens. Insulin-like growth factor II (IGF-II) and its precursor (proIGF-II) are estrogen-regulated mitogens that are over-expressed in breast carcinoma. Thus, I hypothesized that IGF-II/proIGF-II might mediate the biphasic effects of RSV on breast cancer cell growth.</p> <p>The …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… intratibial injection techniques respectively. IGF-1 and its receptor are known to play important roles in both bone metabolism and breast cancer. Therefore a study of the effects of IGF-1 receptor inhibition on tumour cell – bone cell interactions was performed. In vitro studies showed that the …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
Insulin-Like Growth Factor 1 (IGF-1) signalling is known to support oncogenic transformation and the promotion of cancer development. A growing body of evidence has outlined the protective effect IGF-1 signalling has on the mitochondria, however this has been relatively underexplored in cancer. …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… to couple Rab5 activation specifically to the IGF-1 signal transduction pathway via its regulation of IGF-1 receptor endocytosis. This function of Alsin was shown to be essential for IGF-1-mediated cell survival. These results provide the first characterization of Alsin and identify a novel …
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Genexpression der GH- IGF-1 Kaskade in endokrin aktiven und endokrin inaktiven Hypophysenadenomen
… Da GH über den Insulin-like-growth-factor-1 (IGF-1) eine mitogene Wirkung auf potentiell vorhandenes, postoperatives Tumorrestgewebe entfalten könnte, stellten wir die Frage, ob neben GH und IGF-1 auch der Growth-Hormon-Receptor (GH-R) und der IGF-1-Receptor (IGF-1-R) exprimiert werden und …
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
The IGF-1R has long been implicated in numerous malignant characteristics of cancers including enhanced proliferation, insensitivity to apoptosis, chemoresistance, increased migratory and invasive capacity, epithelial-to-mesenchymal transition, and metabolic augmentation. IGF-1R, much like other …
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
… these cells. In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated progenitor cells. One particular enzyme activated by both IGF-I and IL-4 is phosphatidylinositol 3$\sp\prime$-kinase, a lipid kinase which …
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