Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 364 for “"IGF"”.
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A study on the interactions of synthetic IGF-II analogues with the type 1 IGF and insulin receptors.
Insulin-like growth factor II (IGF-II) is a unique regulatory peptide containing 67 residues and three disulfide bonds. It binds with high affinity to three receptors, the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF-1R) and the We 2 insulin-like growth factor receptor …
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Characterization of the IGF system in food-restricted pregnant and lactating rats: Role of IGF-I in nutrient partitioning
… this adaptation. To investigate the role of the IGF-I in adaptation to dietary restriction, the experiments reported herein determined the changes in the circulating levels, as well as, in the gene expression of IGF-I and IGFBPs in pregnant and lactating rats which were food restricted during …
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Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… between the endocrine and immune systems. IGF-I is a critical anabolic factor that promotes growth and regeneration of skeletal muscle. Conversely, elevated levels of proinflammatory cytokines are associated with reduced anabolic activity of IGF-I and increased loss of muscle mass that …
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Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
… in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show that there is a pH dependence in the association of IGF-I with the …
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Charakterisierung von Proteinen und Untersuchung des IGF-Systems im Eberseminalplasma
… und Hybridebergruppen einerseits Komponenten des IGF-Systems im Eberseminalplasma zu identifizieren und ihren Einfluss auf die Fertilität zu überprüfen, andererseits mittels der Proteomics-Technik das komplexe Proteingemisch im Eberseminalplasma zu analysieren. Es wurde das Vorhandensein von …
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Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster
… conserved nutrient-sensing Insulin/IGF-like signalling (IIS) pathway. IIS interacts with multiple cellular processes, including cell growth, development, metabolic homeostasis, fecundity and stress resistance. Evidence has revealed a strong connection between systemically reduced IIS …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… (IL-1beta) and interleukin-6 (IL-6), inhibit IGF-I-promoted DNA synthesis in human MCF-7 breast adenocarcinoma cells, T-47D breast ductal carcinoma cells, murine FDCP progenitor myeloid cells and human promyeloid HL-60 cells. Flow cytometry confirmed that all three cytokines suppress …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell lines were developed …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic malignancies and in the process of SV40-mediated malignant transformation of human cells. We have found that in SV40-transformed human mesothelial cells (HM) the Large T antigen (Tag), p53, pRb …
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… by estrogens. Insulin-like growth factor II (IGF-II) and its precursor (proIGF-II) are estrogen-regulated mitogens that are over-expressed in breast carcinoma. Thus, I hypothesized that IGF-II/proIGF-II might mediate the biphasic effects of RSV on breast cancer cell growth.</p> <p>The …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… intratibial injection techniques respectively. IGF-1 and its receptor are known to play important roles in both bone metabolism and breast cancer. Therefore a study of the effects of IGF-1 receptor inhibition on tumour cell – bone cell interactions was performed. In vitro studies showed that the …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
Insulin-Like Growth Factor 1 (IGF-1) signalling is known to support oncogenic transformation and the promotion of cancer development. A growing body of evidence has outlined the protective effect IGF-1 signalling has on the mitochondria, however this has been relatively underexplored in cancer. …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… to couple Rab5 activation specifically to the IGF-1 signal transduction pathway via its regulation of IGF-1 receptor endocytosis. This function of Alsin was shown to be essential for IGF-1-mediated cell survival. These results provide the first characterization of Alsin and identify a novel …
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Genexpression der GH- IGF-1 Kaskade in endokrin aktiven und endokrin inaktiven Hypophysenadenomen
… Da GH über den Insulin-like-growth-factor-1 (IGF-1) eine mitogene Wirkung auf potentiell vorhandenes, postoperatives Tumorrestgewebe entfalten könnte, stellten wir die Frage, ob neben GH und IGF-1 auch der Growth-Hormon-Receptor (GH-R) und der IGF-1-Receptor (IGF-1-R) exprimiert werden und …
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
The IGF-1R has long been implicated in numerous malignant characteristics of cancers including enhanced proliferation, insensitivity to apoptosis, chemoresistance, increased migratory and invasive capacity, epithelial-to-mesenchymal transition, and metabolic augmentation. IGF-1R, much like other …
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
… these cells. In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated progenitor cells. One particular enzyme activated by both IGF-I and IL-4 is phosphatidylinositol 3$\sp\prime$-kinase, a lipid kinase which …
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The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects
… known as the Insulin-like Growth Factors (IGFs) hâve been identified and shown to share insulin's biological activities. Thèse, too, are thought to play an important rôle in the growth and development of the fétus. Due to the structural similarities, insulin and the IGFs m a y bind with …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was …
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