Quantitative lactate-specific magnetic resonance imaging and proton spectroscopy of muscle and brain

The techniques of magnetic resonance (MR) imaging and spectroscopy have recently garnered much attention as tools for detecting and localizing metabolic changes in living tissues in various pathologic states and during physiologic activation. For example, in studies employing localized MR spectroscopy (MRS) or spectroscopic imaging (MRSI), increases in lactate levels above those in normal, resting tissues have been shown to be associated with disease states such as stroke and tumors, as well as with activated states such as muscular exercise and neural activity. Using different principles, the technique of functional MRI (fMRI) can reveal, in studies of normal brain, neural activation based upon differences, between resting and activated states, of local blood flow, blood volume, and deoxyhemoglobin concentration, which change the apparent NMR relaxation times T$\sb1$ and T$\sb2$ of water around the area of activation.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics and Computational Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Kmiecik, Joseph Anthony

Contributors dc:contributor

• Dawson, M. Joan

• Biology, Animal Physiology
• Health Sciences, Radiology
• Biophysics, Medical

Statement dc:rights

• Copyright 1996 Kmiecik, Joseph Anthony

Language dc:language

eng

Identifier

9780591198652
AAI9712334
(UMI)AAI9712334

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22425