Analysis of the roles of ligand and DNA binding in estrogen receptor action

In the first part of this work we provide evidence indicating that under standard cell culture conditions unliganded estrogen receptor (ER) is unable to activate transcription. Studies of Chinese Hamster Ovary cells which were grown under serum-free conditions, suggested that commercial base media may contain traces of estrogenic compounds. Additional studies demonstrated that transcriptional synergy by ER is strongly dependent on both cell-type and ER concentration, and is likely due to the cooperative binding of ER to adjacent estrogen response elements (EREs).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Mattick, Sandra Kay

Contributors dc:contributor

• Shapiro, David J.

• Biology, Molecular
• Biology, Cell
• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1996 Mattick, Sandra Kay

Language dc:language

eng

Identifier

9780591199376
AAI9712372
(UMI)AAI9712372

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22308