University of Illinois at Urbana-Champaign
Investigations of chiral recognition of conformationally rigid chiral stationary phases
Abstract
dc:descriptionFrom mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from α-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. π-Acidic α-amino-β-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized β-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of π-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB π-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Lee, Wonjae
- Contributors dc:contributor
-
- Pirkle, William H.
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- Copyright 1994 Lee, Wonjae
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
-
AAI9512455
(UMI)AAI9512455 - OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/22235