{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/22235"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/22235","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Investigations of chiral recognition of conformationally rigid chiral stationary phases","abstract":"From mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from $\\alpha$-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. $\\pi$-Acidic $\\alpha$-amino-$\\beta$-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized $\\beta$-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of $\\pi$-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB $\\pi$-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.","abstract_html":"From mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from <span class=\"etd-inline-math\">&alpha;</span>-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. <span class=\"etd-inline-math\">&pi;</span>-Acidic <span class=\"etd-inline-math\">&alpha;</span>-amino-<span class=\"etd-inline-math\">&beta;</span>-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized <span class=\"etd-inline-math\">&beta;</span>-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of <span class=\"etd-inline-math\">&pi;</span>-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB <span class=\"etd-inline-math\">&pi;</span>-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.","abstract_has_math":true,"creators":["Lee, Wonjae"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Pirkle, William H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:33:23Z","date_published":"2011-05-07T13:33:23Z","updated_at":"2026-07-22T22:25:19Z","subjects":["Chemistry, Organic"],"languages":["eng"],"rights":["Copyright 1994 Lee, Wonjae"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512455","(UMI)AAI9512455"],"render_values":[{"text":"AAI9512455","href":null,"code":true},{"text":"(UMI)AAI9512455","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/22235","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pirkle, William H."]},{"key":"dc:creator","label":"Author","values":["Lee, Wonjae"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:33:23Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Lee, Wonjae"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512455","(UMI)AAI9512455","http://hdl.handle.net/2142/22235"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["From mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from $\\alpha$-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. $\\pi$-Acidic $\\alpha$-amino-$\\beta$-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized $\\beta$-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of $\\pi$-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB $\\pi$-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.","Made available in DSpace on 2011-05-07T13:33:23Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9512455.pdf: 5046572 bytes, checksum: 519b9c0ee70d3aec2d845f70ab60842d (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:56:14Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:26:16-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Investigations of chiral recognition of conformationally rigid chiral stationary phases"]}]}],"canonical_facts":{"dc:contributor":["Pirkle, William H."],"dc:creator":["Lee, Wonjae"],"dc:date":["2011-05-07T13:33:23Z","10000-01-01","1994"],"dc:description":["From mechanistic considerations, the development of conformationally rigid chiral stationary phases (CSPs) has been a goal. Several conformationally rigid CSPs derived from $\\alpha$-amino-lactams have been prepared and their abilities to separate the enantiomers of a variety of analytes have been evaluated. $\\pi$-Acidic $\\alpha$-amino-$\\beta$-lactam-derived CSPs have been designed specifically for the enantioseparation of underivatized $\\beta$-blockers. A systematic study of chromatographic structure-activity relationships for the resolution of $\\pi$-acidic dinitrobenzoyl (DNB) amino acid derivatives on several DNB $\\pi$-acidic CSPs has been carried out. Related to these studies, X-ray crystallographic structure determinations have been pursued in a quest for the origins of chiral-self recognition.","Made available in DSpace on 2011-05-07T13:33:23Z (GMT). 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