Pathophysiologic effects of anatoxin-a(s), a toxin from the cyanobacterium Anabaena flos-aquae

Extracts containing anatoxin-a(s) (antx-a(s)) or purified antx-a(s) from Anabaena flos-aquae NRC 525-17 were evaluated for effects on brain (whole brain or cortex, medulla, midbrain, hippocampus, hypothalamus, olfactory lobes, striatum, and the anterior cervical spinal cord) cholinesterase (ChE) in vivo after parenteral administration to mice, rats, and swine. Antx-a(s) did not inhibit ChE in these tissues, but did cause clinical signs, inhibition of plasma, red blood cell (RBC) and/or whole blood ChE, and lethality, suggesting that the toxin is unable to cross the blood brain barrier and is strictly an inhibitor of peripheral ChE. A similar pattern of ChE inhibition was observed in mice, swine, ducks, and a steer given extracts of 3 different algal blooms containing ChE-inhibiting toxin(s).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biology, Veterinary Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Cook, William Oscar, II

Contributors dc:contributor

• Beasley, Val Richard

• Biology, Veterinary Science

Statement dc:rights

• Copyright 1989 Cook, William Oscar, II

Language dc:language

eng

Identifier

AAI9010837
(UMI)AAI9010837

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21958