Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"parenteral administration"”.
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… substance, the formulation and/or the route of administration) with the physiological environment occur. These limitations are particularly evident for parenteral administration routes, such as subcutaneous and intradermal delivery, where the structural and compositional complexity of the …
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Acute Selenium Toxicosis in Sheep
… produced by sodium selenite in sheep following parenteral administration were evaluated.
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Pathophysiologic effects of anatoxin-a(s), a toxin from the cyanobacterium Anabaena flos-aquae
… spinal cord) cholinesterase (ChE) in vivo after parenteral administration to mice, rats, and swine. Antx-a(s) did not inhibit ChE in these tissues, but did cause clinical signs, inhibition of plasma, red blood cell (RBC) and/or whole blood ChE, and lethality, suggesting that the toxin is unable …
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Contagious ecthyma virus infection of sheep: virologic and immunologic investigations
… levels of systemic immunity may be induced by parenteral administration of live CE vaccines compared to the current procedure of inducing a localized skin infection. Replication of CE virus in buffy coat cells in vitro suggested that the virus may replicate in macrophages and therefore …
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Non-ionic surfactant vesicles as an Amphotericin B inhaled delivery system for the treatment of leishmaniasis
… limited by instability at tropical temperature, parenteral administration, renal toxicity (Fungizone®) or cost (AmBisome®, Amphotec® and Abelcet®). In this study, inhaled AmB non-ionic surfactant vesicles (AmB-NIV) were assessed as an alternative AmB formulation, which should reduce costs, …
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Antileishmania Compounds From An Unidentified Endophytic Fungus And Biotransformation Of 5,7,2`,4`,5`-Pentahydroxyflavonol
… are often inadequate, requiring long courses of parenteral administration, having toxic side effects or becoming less effective due to the emergence of resistant strains. Thus, there is an urgent need for new, effective, and inexpensive drugs. In the fight against leishmaniasis, natural products …
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Administration of arginine does not alter material circulating concentration of C-type natriuretic peptide in pregnant sheep: A thesis submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours
… fetuses than in those with singletons. Because parenteral administration of arginine can mitigate the nutritional constraint that occurs in multi-fetal pregnancies, it was hypothesised that treatment with arginine would decrease plasma CNP concentration in ewes pregnant with triplets, but have …
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Bio-Inspired and Nanotechnology-Enabled Drug Delivery for Diabetes and Brain Cancer
… colloidal stability and low systemic toxicity. Parenteral administration of the nanoparticle formulations enabled delivery of blood-brain barrier-impermeable compounds to the brain in healthy mice. Systemic administration of the nanoparticles loaded with clinically relevant doses of drug in …
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Anti-malaria drug treatment in Vietnam
… of severe malaria in adults. The rectal administration of artemisinin would obviollsly constitute a useful therapeutic advance, in comparing with parenteral drugs such as artemether and artesunate, particularly in areas where parenteral administration is difficult.<br></br><br></br> 3/ …
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Interactions of sodium ethacrynate in intravenous admixture with selected cardiovascular and psychotherapeutic agents
… agents. This is especially true in the case of parenteral administration when one must be aware not only of therapeutic interactions but also chemical and physical reactions that might occur.</p><p>In order to avoid incompatibilities, drug manufacturers have suggested that parenteral solutions …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… best strategies to realize sSLN, suitable for parenteral administration, were to coat the CUR-SLN surface with hydrophilic polymer PEG (CUR-pSLN), while the AST-SLN with surfactant polysorbate 80 (AST-p80SLN). CUR-pSLNs were prepared by the solvent evaporation method obtaining spherical …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
Most conventional vaccines are administered parenterally (e.g., by intramuscular (IM) or intradermal (ID) injection) and induce systemic but rarely mucosal immunity. Novel vaccination strategies capable of inducing both systemic and mucosal immune responses could greatly reduce infection and …
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Novel Delivery Systems For Iron Replenishment
… chronic conditions. Oral iron salts or colloidal parenteral iron formulations are treatment options for iron replenishment since several decades, but they are associated with severe side effects along with other patient noncompliance issues. Transdermal delivery of iron could be a potential …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… oral mucosal diseases and as an alternative to parenteral administration for the systemic delivery of drugs. Results showed good penetration of polymersomes into the oral mucosa and the multi-cellular tumour spheroids demonstrating the potential to develop these drug delivery vehicles to deliver …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
… in peptide oral solid dosage forms. While parenteral administration remains the clinical standard, oral delivery is highly desirable for its advantages in patient preference, improved compliance, and more physiologically relevant absorption. Conventional tablet manufacturing techniques, …
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Nose to Brain Delivery of Therapeutic Agents
… system are invasive and do not allow frequent administration. Brain targeting of drugs by intranasal route is a safe and noninvasive method of drug delivery which allows frequent administration and is certainly more patient compliant than the currently folloinvasive methods. In this study, the …
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Development of nanoparticles for oral delivery of insulin
Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the …
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Comparitive activities and mechanisms of action of three novel antiulcer agents
… a very short duration and is only active after parenteral administration. In a view to find out the mechanism of action of these drugs on gastric acid secretion, isolated gastric glands from rabbits were employed as an in vitro technique using radiolabeled 14C-aminopyrine as a marker. The …
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Effects of estrogen on the B cell functions of normal mice
… and cancer. These studies were accomplished by parenteral administration of estrogen to nonautoimmune C57BL/6 mice, a widely used strain in immunology. In these mice, we found that treatment with estrogen, but not 5a-dihydrotestosterone. induced the expression of a wide variety of IgG and IgM …
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