Modulation of TGF-beta and extracellular matrix in retionic acid-induced cleft palate

The morphologic findings of altered mesenchymal organization and delayed elevation of the palatal shelves indicate RA-induced changes in palatal shelf extracellular matrix. The patterns of localization of collagen I, III, and IV, fibronectin, tenascin, laminin and hyaluronate were investigated in normal palate development. Collagen I and collagen IV, laminin, and hyaluronate proved to have spatial-temporal patterns of localization during palatal shelf growth and reorientation. However, using immunohistochemistry, RA-induced changes in these molecules could not be demonstrated.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Biosciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Degitz, Sigmund Jay, Jr.

Contributors dc:contributor

• Francis, Bettina M.

• Health Sciences, Toxicology
• Health Sciences, Human Development

Statement dc:rights

• Copyright 1996 Degitz, Sigmund Jay, Jr

Language dc:language

eng

Identifier

AAI9712250
(UMI)AAI9712250

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/21213