Studies on the regulation in vivo and structure/function relationships of the enzyme 5-phosphoribosyl-alpha-1-pyrophosphate synthetase from Salmonella typhimurium

Little is known about the amino acids present in the active site of the enzyme phosphoribosylpyrophosphate (PRPP) synthetase or the regulation of the structural gene (prs) in vivo. Site directed mutagenesis and characterization of mutant proteins were used to examine possible residues involved in catalysis. Initial studies of the transcriptional regulation of the prs gene were also conducted.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Post, David A.

Contributors dc:contributor

• Switzer, Robert L.

• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1992 Post, David A.

Language dc:language

eng

Identifier

AAI9215870
(UMI)AAI9215870

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20984