Lipoate-protein and biotin-protein ligases of Escherichia coli

Lipoate and biotin are critical and almost universally distributed cofactors which share striking parallels. Both cofactors are covalently attached to specific lysine residues of specific apoprotein domains, and thus function as protein bound carriers of reaction intermediates between separate active sites of multienzyme complexes. Escherichia coli synthesizes both compounds and also expresses a set of dedicated, highly specific cofactor-apoprotein ligases to generate protein bound lipoyl and biotinyl groups.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Morris, Timothy William

Contributors dc:contributor

• Cronan, John E.

• Biology, Genetics
• Biology, Microbiology
• Chemistry, Biochemistry

Statement dc:rights

• Copyright 1994 Morris, Timothy William

Language dc:language

eng

Identifier

AAI9512492
(UMI)AAI9512492

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20505