Evaluation of the pre-ruminant calf as a model for the study of beta-carotene metabolism in the human

This manuscript chronicles the evaluation and development of the preruminant calf as a model for the study of the absorption, transport and metabolism of β-carotene in the human. The pattern of serum appearance and disappearance of β-carotene following oral dosing was favorably compared to humans, and kinetic analysis of serum curves resulted in a serum elimination constant (0.006/h) which was identical to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of β-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues were also significantly elevated after a dose of β-carotene. The preruminant calf has shown the ability to absorb β-carotene from both purified and vegetable sources. Conversion of β-carotene to vitamin A in vivo also was demonstrated using radiolabeled β-carotene, and radiolabeled retinol and retinyl esters were recovered from liver, adrenal and intestinal tissues. Radiolabeled intermediates in the conversion of β-carotene to vitamin A were not detected.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Poor, Christopher Lee

Contributors dc:contributor

• Fahey, George C.

• Agriculture, Animal Culture and Nutrition
• Health Sciences, Nutrition

Statement dc:rights

• Copyright 1994 Poor, Christopher Lee

Language dc:language

eng

Identifier

AAI9503299
(UMI)AAI9503299

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20386