{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20386"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20386","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Evaluation of the pre-ruminant calf as a model for the study of beta-carotene metabolism in the human","abstract":"This manuscript chronicles the evaluation and development of the preruminant calf as a model for the study of the absorption, transport and metabolism of $\\beta$-carotene in the human. The pattern of serum appearance and disappearance of $\\beta$-carotene following oral dosing was favorably compared to humans, and kinetic analysis of serum curves resulted in a serum elimination constant (0.006/h) which was identical to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of $\\beta$-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues were also significantly elevated after a dose of $\\beta$-carotene. The preruminant calf has shown the ability to absorb $\\beta$-carotene from both purified and vegetable sources. Conversion of $\\beta$-carotene to vitamin A in vivo also was demonstrated using radiolabeled $\\beta$-carotene, and radiolabeled retinol and retinyl esters were recovered from liver, adrenal and intestinal tissues. Radiolabeled intermediates in the conversion of $\\beta$-carotene to vitamin A were not detected.","abstract_html":"This manuscript chronicles the evaluation and development of the preruminant calf as a model for the study of the absorption, transport and metabolism of <span class=\"etd-inline-math\">&beta;</span>-carotene in the human. The pattern of serum appearance and disappearance of <span class=\"etd-inline-math\">&beta;</span>-carotene following oral dosing was favorably compared to humans, and kinetic analysis of serum curves resulted in a serum elimination constant (0.006/h) which was identical to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of <span class=\"etd-inline-math\">&beta;</span>-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues were also significantly elevated after a dose of <span class=\"etd-inline-math\">&beta;</span>-carotene. The preruminant calf has shown the ability to absorb <span class=\"etd-inline-math\">&beta;</span>-carotene from both purified and vegetable sources. Conversion of <span class=\"etd-inline-math\">&beta;</span>-carotene to vitamin A in vivo also was demonstrated using radiolabeled <span class=\"etd-inline-math\">&beta;</span>-carotene, and radiolabeled retinol and retinyl esters were recovered from liver, adrenal and intestinal tissues. Radiolabeled intermediates in the conversion of <span class=\"etd-inline-math\">&beta;</span>-carotene to vitamin A were not detected.","abstract_has_math":true,"creators":["Poor, Christopher Lee"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Fahey, George C."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:37:44Z","date_published":"2011-05-07T12:37:44Z","updated_at":"2026-07-22T22:25:15Z","subjects":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"],"languages":["eng"],"rights":["Copyright 1994 Poor, Christopher Lee"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9503299","(UMI)AAI9503299"],"render_values":[{"text":"AAI9503299","href":null,"code":true},{"text":"(UMI)AAI9503299","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20386","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Fahey, George C."]},{"key":"dc:creator","label":"Author","values":["Poor, Christopher Lee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:37:44Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Poor, Christopher Lee"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9503299","(UMI)AAI9503299","http://hdl.handle.net/2142/20386"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This manuscript chronicles the evaluation and development of the preruminant calf as a model for the study of the absorption, transport and metabolism of $\\beta$-carotene in the human. The pattern of serum appearance and disappearance of $\\beta$-carotene following oral dosing was favorably compared to humans, and kinetic analysis of serum curves resulted in a serum elimination constant (0.006/h) which was identical to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of $\\beta$-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues were also significantly elevated after a dose of $\\beta$-carotene. The preruminant calf has shown the ability to absorb $\\beta$-carotene from both purified and vegetable sources. Conversion of $\\beta$-carotene to vitamin A in vivo also was demonstrated using radiolabeled $\\beta$-carotene, and radiolabeled retinol and retinyl esters were recovered from liver, adrenal and intestinal tissues. Radiolabeled intermediates in the conversion of $\\beta$-carotene to vitamin A were not detected.","This work has demonstrated the appropriateness of the preruminant calf model. The usefulness of the model for a given study must be determined after careful consideration of the strengths and weaknesses of the model. The hindrance of the calf's relatively great size, special needs for housing, handling and slaughter facilities and high expense must be balanced against the unique value of an animal which can easily provide multiple blood samples, will readily consume unusual foods and is large, docile and hardy enough to undergo various surgical procedures.","Made available in DSpace on 2011-05-07T12:37:44Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503299.pdf: 5636482 bytes, checksum: daafcc590a8bda4f52f9f51905fd58f4 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:43:33Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:19:04-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Evaluation of the pre-ruminant calf as a model for the study of beta-carotene metabolism in the human"]}]}],"canonical_facts":{"dc:contributor":["Fahey, George C."],"dc:creator":["Poor, Christopher Lee"],"dc:date":["2011-05-07T12:37:44Z","10000-01-01","1994"],"dc:description":["This manuscript chronicles the evaluation and development of the preruminant calf as a model for the study of the absorption, transport and metabolism of $\\beta$-carotene in the human. The pattern of serum appearance and disappearance of $\\beta$-carotene following oral dosing was favorably compared to humans, and kinetic analysis of serum curves resulted in a serum elimination constant (0.006/h) which was identical to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of $\\beta$-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues were also significantly elevated after a dose of $\\beta$-carotene. The preruminant calf has shown the ability to absorb $\\beta$-carotene from both purified and vegetable sources. Conversion of $\\beta$-carotene to vitamin A in vivo also was demonstrated using radiolabeled $\\beta$-carotene, and radiolabeled retinol and retinyl esters were recovered from liver, adrenal and intestinal tissues. Radiolabeled intermediates in the conversion of $\\beta$-carotene to vitamin A were not detected.","This work has demonstrated the appropriateness of the preruminant calf model. The usefulness of the model for a given study must be determined after careful consideration of the strengths and weaknesses of the model. The hindrance of the calf's relatively great size, special needs for housing, handling and slaughter facilities and high expense must be balanced against the unique value of an animal which can easily provide multiple blood samples, will readily consume unusual foods and is large, docile and hardy enough to undergo various surgical procedures.","Made available in DSpace on 2011-05-07T12:37:44Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503299.pdf: 5636482 bytes, checksum: daafcc590a8bda4f52f9f51905fd58f4 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:43:33Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:19:04-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9503299","(UMI)AAI9503299","http://hdl.handle.net/2142/20386"],"dc:language":["eng"],"dc:rights":["Copyright 1994 Poor, Christopher Lee"],"dc:subject":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"],"dc:title":["Evaluation of the pre-ruminant calf as a model for the study of beta-carotene metabolism in the human"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:15Z"}