University of Illinois at Urbana-Champaign
Abnormal regulation of T lymphocytes from aged rats contributes to immunosenescence
Abstract
dc:descriptionRegulation of T lymphocyte proliferation from aged rats was explored by activating lymphocytes to proliferate with the T cell lectin Con A, the calcium ionophores A23187 and ionomycin and the protein kinase C activator, PMA. Similar to human T lymphocytes, but unlike mouse lymphocytes, rat splenocytes and T lymphocytes proliferate in response to calcium ionophores in the absence of detectable IL 2 or IL 4. Proliferation in response to ionomycin and A23187 increases as early as 6 months of age and continues to rise until 24 months of age, and this increase precedes the decline in proliferative responses of splenocytes to Con A. The enhanced response of splenocytes and T lymphocytes to ionomycin is a newly-defined, very sensitive biomarker of aging.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Animal Sciences
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Franklin, Richard Arnold
- Contributors dc:contributor
-
- Kelley, Keith W.
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- Copyright 1989 Franklin, Richard Arnold
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
-
AAI9010858
(UMI)AAI9010858 - OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/20216