Characterization of a T cell receptor and its ligands

Cytotoxic T lymphocytes (CTL) recognize and lyse cells presenting viral or tumor-associated antigens associated with class I major histocompatibility complex proteins. Recognition occurs between the T cell receptor (TCR) and a complex of an antigenic peptide/major histocompatibility complex (MHC) product. In addition, the CD8 molecule of the CTL stabilizes the interaction by binding the constant domain of the MHC product. Clone 2C recognizes a peptide (p2C) bound to the MHC product L$\sp{\rm d}.$ L$\sp{\rm d}$ levels expressed by a panel of tumor cells directly correlated with their ability to be lysed and incubation of target cells with exogenous p2C led to increased lysis by CTL 2C which was inhibited minimally with anti-CD8 or anti-TCR antibodies. Thus at high ligand densities, very few TCR molecules/2C cell are needed for recognition.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Soo Hoo, William

Contributors dc:contributor

• Kranz, David M.

• Biology, Molecular
• Biology, Cell
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1993 Soo Hoo, William

Language dc:language

eng

Identifier

AAI9314942
(UMI)AAI9314942

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/19713