Genetic dissection of proline transport by Salmonella typhimurium

Transport is an essential and often rate-limiting step in the growth and metabolism of cells. However, very little is known about the molecular mechanism of substrate transport. Proline transport by Salmonella typhimurium is a good model system for studying the molecular mechanism of ion-driven transport systems. The putP gene encodes proline permease, a sodium/proline symport system. In order to identify the active site of proline permease, we isolated a large number of rare putP missense mutations that alter the kinetics and specificity of transport.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Myers, Richard Stanley

Contributors dc:contributor

• Maloy, Stanley R.

• Biology, Microbiology

Statement dc:rights

• Copyright 1989 Myers, Richard Stanley

Language dc:language

eng

Identifier

AAI8924910
(UMI)AAI8924910

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/18985