Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 195 for “"Rate-Limiting Step"”.
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Investigating the rate-limiting step of mitochondrial complex I catalysis
… proton translocation remains unclear. First, the rate-limiting step of catalysis in complex I was investigated from the point of view of the proton. Using the proteoliposomes system, the pH and solvent isotope dependence of kinetic parameters of purified bovine and *Yarrowia lipolytica* complex I …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
<p>ABSTRACT RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS By Frank Sungping Chen Advisor: Ching-Kang Jason Chen, Ph.D. Retinal photoreceptors provide the first gateway in which light information from the environment is transformed into neuronal signals. The …
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Quantitative structure activity relationships of monoamine oxidase catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
… structure act! Vlty relationships of rate s of I-methyl-4-phenyl-l,2,3,6-tetrahydropyridine oxidation catalyzed by monoamine oxidases A and B were performed to elucidate active site substrate conformation and oxidation mechanisms. Plotting experimental kinetic activity against …
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Structure, function, and evolution of proline transport systems in Salmonella typhimurium
Solute transport is an essential and often the rate-limiting step in metabolism and energy utilization. Nutrient uptake across the cytoplasmic membrane is mediated by integral membrane proteins called permeases. The goal of this research was to understand the structure and function of the substrate …
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Mechanism of oxygen reduction reaction on transition metal oxide catalysts for high temperature fuel cells
… it has the disadvantage of having to operate at elevated temperatures (>800°C) due to the poor catalytic activity of the oxygen reducing cathode. This thesis research is focused on identifying the fundamental reaction mechanisms and pathways for oxygen reduction reaction (ORR) in …
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Genetic dissection of proline transport by Salmonella typhimurium
Transport is an essential and often rate-limiting step in the growth and metabolism of cells. However, very little is known about the molecular mechanism of substrate transport. Proline transport by Salmonella typhimurium is a good model system for studying the molecular mechanism of ion-driven …
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Identifying non-value added waste that delay emergency CT brain workflow using lean management principles
… of the nonvalue-added waste (NVAW) (steps regarded as wasteful to the customer) in the CT brain workflow can be determined by use of a lean management tool namely a value stream map (VSM - a flow analysis of information required to provide service to the customer). AIM: The study aims …
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Relation between surface structural and chemical properties of platinum nanoparticles and their catalytic activity in the decomposition of hydrogen peroxide
… nanocatalysts and determine the mechanism and rate-limiting step of the reaction. To this end, we have characterized two commercial platinum nanocatalysts, known as platinum black and platinum nanopowder, and studied the effect of different reaction conditions on their rates of H₂O₂ …
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Optimizing Adsorption Energies of Reaction Products and Intermediates on Metal/Metal Oxide Catalysts to Achieve High Activity and Tunable Selectivity in Solid-Gas Phase Reactions
… to be studied and understood to determine the rate-limiting step. Based on that, better design of process and catalyst composition can be developed for efficiently producing a desirable product. In Chapter 2, the rate-limiting step for producing methanol in CO2 hydrogenation reaction under …
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Studies on the Flavin Binding Properties of Native and Protease-Activated Pyruvate Oxidase From Escherichia Coli
… form an initial monomer-FAD complex is fast. The rate limiting step for enzymatic reactivation appears to be the folding of the polypeptide chain in the monomer-FAD complex to reconstitute the three dimensional FAD binding site prior to subunit reassociation. The subsequent formation of native …
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
Induction of angiogenesis is a critical and rate-limiting step in the progression of cancer. It is widely acknowledged that this induction requires the concomitant stimulation of pro-angiogenic and repression of anti-angiogenic proteins. It has been demonstrated that in human epithelial cells …
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Sphingolipids in Toxoplasma gondii; synthesis and scavenging
… Serine palmitoyltransferase is the first rate limiting step in biosynthesis and the inhibition of this enzyme has proved lethal in many organisms. This enzyme is currently uncharacterized in T.gondii and other Apicomplexa. In this work the evolutionary origins, function and the cellular …
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ORGANOMETALLIC AND PHOTOCHEMISTRY OF CERIUM AND THORIUM COMPLEXES AND PHOTOCATALYTIC SYSTEMS FOR THE GENERATION OF CHLORINE RADICALS.
… of the cerium complexes, and 3) systems that generates chlorine radicals. For theIn search of new coordination chemistry offor high oxidation state (+4) lanthanides, we investigated several ligand frameworks, including glutarimide dioxime (chapter 2), TriNOx3− (chapter 3 with alkyne ligands, …
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Computational Investigations at the Gas-Surface Interface: Organic Surface Oxidation and Hydrolysis of Chemical Warfare Agents and Simulants
… ozone with C60-fullerene and the products of nitrate addition to a vinyl-terminated self-assembled monolayer. In the first system, we followed a reaction pathway beginning with primary ozonide formation through the formation of stable products. Theoretical vibrational spectra were used to …
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Improving gas fixation in acetogenic bacteria
… biological limitations such as slow growth rates, and low biomass and product titers. Process limitations are also a concern, as full conversion is desirable and gas mass transfer can be a substantial rate limiting step.
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Generation and Characterization of dszB Mutants from Nocardia asteroides A3H1
… “4S”desulfurization pathway. In the final and rate-limiting step of this pathway, the DszB enzyme catalyzes the hydrolysis of 2-(2’- hydroxyphenyl) benzenesulfinate to form inorganic sulfur and 2-hydroxybiphenyl. The wildtype dszB gene from A3H1 was successfully cloned into the pBAD TOPO® and …
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The Effects of Accessory Proteins on ENaC Function
… channels, also known as ENaC, constitute the rate-limiting step of sodium reabsorption in the distal tubules of the nephron in the kidneys. It is here the final, yet critical, 3% to 5% of sodium reabsorption that dictates blood pressure occurs. In this study, β-ENaC was cloned into pESC-Leu …
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… mainly the statins. In this study, we demonstrated that exposure of leukemia cell lines to lovastatin (20 uM, 18 hours) and UCN-01 (100 nM, 18 hours) resulted in mitochondria dysfunction, procaspase 3 and 9 cleavage, and PAW degradation along with marked cytochrome C release and apoptosis. …
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Vo(2) transitional response to a crossover from priming exercise
… regarding oxygen uptake kinetics centers on the rate-limiting step. This study was designed to observe the oxygen uptake response that occurs between a crossover of modes of priming exercises. Participants completed three exercise trials. Trial 1 involved cycling from rest to a target workload, …
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COMT Genotype, Schizophrenia, and Dopamine Transmission
… receptor, COMT, and tyrosine hydroxylase, the rate-limiting step of dopamine synthesis. The current findings support a model decreased dopamine synthesis and increased catabolism leading to deficient dopamine signal transmission in persons with schizophrenia.
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