A portable, smartphone-linked, and miniaturized photonic resonator absorption microscope (PRAM MINI) for point-of-care diagnostics

Point-of-care testing (POCT) has revolutionized healthcare with its rapid, accurate, and all-in-one diagnostic capabilities. In this work, we report the development and validation of the miniaturized Photonic Resonator Absorption Microscope (PRAM Mini), integrated wirelessly with a smartphone application. PRAM Mini harnesses the unique optical coupling of photonic crystal (PC) guided-mode resonance and gold nanoparticle (AuNP) localized surface plasmon resonance to achieve a significant reduction in reflected PC intensity caused by the localized quenching of the AuNP. As an initial demonstration, PRAM Mini effectively detects SARS-CoV-2 antibodies in clinical samples using a blocking biosensor assay. PRAM Mini offers a compact and cost-effective solution for point-of-care diagnostics with text-book-sized dimensions of 23 cm × 21 cm × 10 cm and a total cost of $2,111.65. Its digital resolution quantification features and smartphone-linked functionality enhance accessibility and usability in diverse healthcare settings. The PRAM Mini is a promising tool for addressing the increasing demand for portable and efficient diagnostic solutions, contributing significantly to improved patient care and healthcare system efficiency.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Bioengineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2024

Author dc:creator

• Khemtonglang, Sydney

Contributors dc:contributor

• Cunningham, Brian T

• Photonic Crystals Biosensor
• Absorption Microscopy
• Point-of-care Diagnostics

Statement dc:rights

• Copyright 2024 Sydney Khemtonglang

Language dc:language

en, eng

Handle dc:identifier

https://hdl.handle.net/2142/124586

OAI record oai:identifier

https://www.ideals.illinois.edu/oai-pmh?verb=GetRecord&metadataPrefix=etdms&identifier=oai%3Awww.ideals.illinois.edu%3A2142%2F124586