Defining the relationship between basal myofibrillar protein synthesis and resting metabolic rate

Obesity is a widespread public health crisis with a myriad of contributing factors such as lack of adherence to healthy eating patterns, reduced habitual physical activity, and increased sedentary behavior. While much time has been spent examining the active components that comprise an individual’s net energy balance, less focus has been given towards the passive, basal contributions. Chief among those is resting metabolic rate. The impact of skeletal muscle quantity and quality on resting metabolic rate has been well documented, but the potential influence of muscle protein turnover rates is less well understood. Chronic maintenance of a positive net energy balance (surplus) may lead to obesity, resulting in elevated disease risks. Resting metabolic rate (RMR) is the greatest contributor of total daily energy expenditure (TDEE) and therefore has an important role in weight maintenance. Indeed, increasing habitual physical activity and incorporation of targeted exercise strategies into a life routine can help counterbalance an increased energy surplus in an acute manner, with this relationship being well documented. The maintenance (or growth) of skeletal muscle tissue may also help to passively counteract a chronic energetic surplus due to the significant contribution of skeletal muscle mass, driven by the amount and quality, particularly when compared to other factors such as age. The importance of mixed muscle protein turnover on skeletal muscle quantity and quality, as well as RMR is well understood, but the contribution of specific protein pools or fractions (e.g., myofibrillar protein pool) within the muscle is less well understood. As such, the purpose of this thesis was to fill this research gap by examining the relationship between myofibrillar protein synthesis and RMR in healthy adults. We demonstrated that the specific energetic contribution of basal myofibrillar protein synthesis is insufficient to modulate RMR in healthy adults.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Kinesiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2024

Author dc:creator

• Bein, David William

Contributors dc:contributor

• Burd, Nicholas A

• Skeletal Muscle Mass
• Weight Management
• Muscle Protein Turnover
• Energy Expenditure
• Fractional Synthetic Rate

Statement dc:rights

• Copyright 2024 David Bein

Language dc:language

en, eng

Handle dc:identifier

https://hdl.handle.net/2142/124360

OAI record oai:identifier

https://www.ideals.illinois.edu/oai-pmh?verb=GetRecord&metadataPrefix=etdms&identifier=oai%3Awww.ideals.illinois.edu%3A2142%2F124360