Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition

The primary role of the canine diet is to provide sufficient nutrients to meet the metabolic requirements of dogs. More recently, however, a hypothesis has been supported that, beyond meeting nutritional needs, diet may modulate several functions in the body, which could contribute to reducing the risk of diseases. The use of functional ingredients has contributed to product diversification and the ability to support functional and structural claims in commercial pet foods. These may include weight management or maintenance, skin and coat health, gastrointestinal health, joint health, and more. This dissertation aimed to evaluate the effects of selected functional ingredients in glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in healthy adult dogs. The first aim was to evaluate the longitudinal effects of daily supplementation of Bifidobacterium animalis subsp. lactis CECT 8145 live and heat-killed on weight management, fecal fermentative end-products and microbiota, insulin sensitivity, gut hormones, oxidative stress, inflammatory markers, and white blood cell gene expression of adult dogs. The second aim was to evaluate the effects of dietary inclusion of Ganoderma lucidum (GL) on peripheral blood mononuclear cells (PBMC; T-cells, B-cells, monocytes, and natural killers), vaccine response, nutrient digestibility, fecal fermentative end-products and microbiota, and skin and coat quality of adult dogs. The third aim was to evaluate the longitudinal effects of daily supplementation of incremental doses of inositol on serum oxidative stress, inflammatory biomarkers, gut hormones, and postprandial glycemic and insulinemic responses in overweight dogs. Overall, our results demonstrate that the supplementation of the listed functional ingredients had no detrimental effects to the health status of the dogs. Additionally, the probiotic supplemented appears to influence gene expression for energy metabolism. Due to changes in immune parameters among treatments, GL may exert beneficial immunomodulatory effects in healthy adult dogs when provided at a daily dose of 15 mg/kg BW. We also observed that longitudinal supplementation of inositol may interact with inflammatory response and contribute to the regulation of glucose metabolism.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2023

Author dc:creator

• Kayser, Emanuela

Contributors dc:contributor

• C. de Godoy, Maria R
• Steelman, Andrew
• Swanson, Kelly S.
• Rodriguez-Zas, Sandra
• Fahey, George

• Canine Nutrition
• Functional Ingredients

Statement dc:rights

• Copyright 2023 Emanuela Kayser

Language dc:language

en, eng

Handle dc:identifier

https://hdl.handle.net/2142/122141

OAI record oai:identifier

https://www.ideals.illinois.edu/oai-pmh?verb=GetRecord&metadataPrefix=etdms&identifier=oai%3Awww.ideals.illinois.edu%3A2142%2F122141