{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/122141"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/122141","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01","abstract_has_math":false,"creators":["Kayser, Emanuela"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["C. de Godoy, Maria R","Steelman, Andrew","Swanson, Kelly S.","Rodriguez-Zas, Sandra","Fahey, George"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-12","date_published":"2023-12","updated_at":"2026-07-22T22:25:00Z","subjects":["Canine Nutrition","Functional Ingredients"],"languages":["en","eng"],"rights":["Copyright 2023 Emanuela Kayser"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/122141","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["C. de Godoy, Maria R","Steelman, Andrew","Swanson, Kelly S.","Rodriguez-Zas, Sandra","Fahey, George"]},{"key":"dc:creator","label":"Author","values":["Kayser, Emanuela"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-12","2023-11-30"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Canine Nutrition","Functional Ingredients"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Emanuela Kayser"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/122141"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01","The student, Emanuela Kayser, accepted the attached license on 2023-11-27 at 12:31.","The student, Emanuela Kayser, submitted this Dissertation for approval on 2023-11-27 at 12:44.","This Dissertation was approved for publication on 2023-11-30 at 11:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20019 on 2024-03-01 at 13:31:03","The primary role of the canine diet is to provide sufficient nutrients to meet the metabolic requirements of dogs. More recently, however, a hypothesis has been supported that, beyond meeting nutritional needs, diet may modulate several functions in the body, which could contribute to reducing the risk of diseases. The use of functional ingredients has contributed to product diversification and the ability to support functional and structural claims in commercial pet foods. These may include weight management or maintenance, skin and coat health, gastrointestinal health, joint health, and more. This dissertation aimed to evaluate the effects of selected functional ingredients in glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in healthy adult dogs. The first aim was to evaluate the longitudinal effects of daily supplementation of Bifidobacterium animalis subsp. lactis CECT 8145 live and heat-killed on weight management, fecal fermentative end-products and microbiota, insulin sensitivity, gut hormones, oxidative stress, inflammatory markers, and white blood cell gene expression of adult dogs. The second aim was to evaluate the effects of dietary inclusion of Ganoderma lucidum (GL) on peripheral blood mononuclear cells (PBMC; T-cells, B-cells, monocytes, and natural killers), vaccine response, nutrient digestibility, fecal fermentative end-products and microbiota, and skin and coat quality of adult dogs. The third aim was to evaluate the longitudinal effects of daily supplementation of incremental doses of inositol on serum oxidative stress, inflammatory biomarkers, gut hormones, and postprandial glycemic and insulinemic responses in overweight dogs. Overall, our results demonstrate that the supplementation of the listed functional ingredients had no detrimental effects to the health status of the dogs. Additionally, the probiotic supplemented appears to influence gene expression for energy metabolism. Due to changes in immune parameters among treatments, GL may exert beneficial immunomodulatory effects in healthy adult dogs when provided at a daily dose of 15 mg/kg BW. We also observed that longitudinal supplementation of inositol may interact with inflammatory response and contribute to the regulation of glucose metabolism."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition"]}]}],"canonical_facts":{"dc:contributor":["C. de Godoy, Maria R","Steelman, Andrew","Swanson, Kelly S.","Rodriguez-Zas, Sandra","Fahey, George"],"dc:creator":["Kayser, Emanuela"],"dc:date":["2023-12","2023-11-30"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01","The student, Emanuela Kayser, accepted the attached license on 2023-11-27 at 12:31.","The student, Emanuela Kayser, submitted this Dissertation for approval on 2023-11-27 at 12:44.","This Dissertation was approved for publication on 2023-11-30 at 11:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20019 on 2024-03-01 at 13:31:03","The primary role of the canine diet is to provide sufficient nutrients to meet the metabolic requirements of dogs. More recently, however, a hypothesis has been supported that, beyond meeting nutritional needs, diet may modulate several functions in the body, which could contribute to reducing the risk of diseases. The use of functional ingredients has contributed to product diversification and the ability to support functional and structural claims in commercial pet foods. These may include weight management or maintenance, skin and coat health, gastrointestinal health, joint health, and more. This dissertation aimed to evaluate the effects of selected functional ingredients in glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in healthy adult dogs. The first aim was to evaluate the longitudinal effects of daily supplementation of Bifidobacterium animalis subsp. lactis CECT 8145 live and heat-killed on weight management, fecal fermentative end-products and microbiota, insulin sensitivity, gut hormones, oxidative stress, inflammatory markers, and white blood cell gene expression of adult dogs. The second aim was to evaluate the effects of dietary inclusion of Ganoderma lucidum (GL) on peripheral blood mononuclear cells (PBMC; T-cells, B-cells, monocytes, and natural killers), vaccine response, nutrient digestibility, fecal fermentative end-products and microbiota, and skin and coat quality of adult dogs. The third aim was to evaluate the longitudinal effects of daily supplementation of incremental doses of inositol on serum oxidative stress, inflammatory biomarkers, gut hormones, and postprandial glycemic and insulinemic responses in overweight dogs. Overall, our results demonstrate that the supplementation of the listed functional ingredients had no detrimental effects to the health status of the dogs. Additionally, the probiotic supplemented appears to influence gene expression for energy metabolism. Due to changes in immune parameters among treatments, GL may exert beneficial immunomodulatory effects in healthy adult dogs when provided at a daily dose of 15 mg/kg BW. We also observed that longitudinal supplementation of inositol may interact with inflammatory response and contribute to the regulation of glucose metabolism."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/122141"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Emanuela Kayser"],"dc:subject":["Canine Nutrition","Functional Ingredients"],"dc:title":["Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:00Z"}